All tumors accumulate genetic alterations, some of which can give rise to mutated, non-self peptides presented by human leukocyte antigen (HLA) molecules and elicit T-cell responses.These immunogenic mutated peptides, or neoantigens, are foreign in nature and display exquisite tumor specificity.The correlative evidence suggesting they play an impor
As global environmental change accelerates, biodiversity losses can disrupt interspecific interactions.Extinctions of On-Off Button mutualist partners can create "widow" species, which may face reduced ecological fitness.Hypothetically, such mutualism disruptions could have cascading effects on biodiversity by causing additional species coextinctio
Low saving rates combined with low effective retirement age herald old-age poverty.This paper examines the preferred strategies of future Polish pensioners in order to sustain the standard of living in the future.A two-step approach is used: as a first-best strategy, we explore determinants of supplementary saving with binary logistic models; as a
ALOE ESSENCE The role of the sodium citrate transporter (NaCT) SLC13A5 is multifaceted and context-dependent.While aberrant dysfunction leads to neonatal epilepsy, its therapeutic inhibition protects against metabolic disease.Notably, insights regarding the cellular and molecular mechanisms underlying these phenomena are limited due to the intricac